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Gastric Tolerance of High-Dose Pulse Oral Prednisone in Multiple Sclerosis Neurol 53:2093-2096, Metz,L.M.,et al, 1999 See this aricle in Pubmed Article Abstract Short-term high-dose oral prednisone is not associated with greater gastric damage, as measured with permeability tests, than IV methylprednisolone. High-dose oral prednisone should be considered a first-line treatment option for MS attac k.

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